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CS-W001157 4
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(Bromomethyl)trimethylsilane

  • CAS No. 18243-41-9

  • Cat. No. CS-0196909
  • Purity≥98%
  • MDL No.MFCD00000167

*For research and further manufacturing use only, not for direct human use.

(Bromomethyl)trimethylsilane|CS-0196909

Structure of 18243-41-9

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General Information

  • CAS No. 18243-41-9
  • Cat. No. CS-0196909
  • Purity ≥98%
  • MDL No. MFCD00000167
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₁BrSi
  • Molecular Weight 167.12
  • Synonym(s) (Trimethylsilyl)methyl Bromide
  • SMILES C[Si](C)(C)CBr

Description

Bromomethyltrimethylsilane delivers a reactive bromomethyl group tethered to a silane handle, enabling direct functionalization of nucleophiles. This bench-stable reagent features high selectivity in alkylation reactions and facilitates efficient introduction of trimethylsilyl-protected functionalities under mild conditions.

Application

(Bromomethyl)trimethylsilane serves as a reliable source of the bromomethyl group, enabling efficient alkylation reactions under mild conditions. Its silicon-directed reactivity facilitates selective functionalization of nucleophiles, including amines and thiols, with high chemoselectivity. The trimethylsilyl group enhances stability and simplifies purification, making it well-suited for multi-step synthesis and scale-up applications in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3 (8)
Packing Group : Ⅱ
Hazard Statements : H225-H314-H318
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.2587
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   1

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