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(4-Fluorophenyl)trimethoxysilane

  • CAS No. 53883-61-7

  • Cat. No. CS-0667029
  • Molecule weight216.28
  • Purity≥97%
  • MDL No.MFCD22376646

*For research and further manufacturing use only, not for direct human use.

(4-Fluorophenyl)trimethoxysilane|CS-0667029

Structure of 53883-61-7

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General Information

  • CAS No. 53883-61-7
  • Cat. No. CS-0667029
  • Purity ≥97%
  • MDL No. MFCD22376646
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₃FO₃Si
  • Molecular Weight 216.28
  • Synonym(s) None
  • SMILES CO[Si](C1=CC=C(C=C1)F)(OC)OC

Description

(4-Fluorophenyl)trimethoxysilane features a fluorinated aromatic ring linked to a trimethoxysilyl group, enabling robust coupling to silica surfaces. This combination imparts enhanced hydrolytic stability and directional functionalization in surface modification applications.

Application

(4-Fluorophenyl)trimethoxysilane serves as a versatile silylating agent and building block in organic synthesis, enabling efficient introduction of fluorinated aryl groups under mild conditions. Its trimethoxysilyl moiety offers excellent hydrolytic stability and facilitates coupling reactions via Si–O bond formation, with broad compatibility across functional groups. The compound functions as a key intermediate in the construction of fluorinated heterocycles and silicon-based molecular architectures, particularly valuable in medicinal chemistry and materials science applications requiring robust, bench-stable reagents.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H302-H373
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P270-P280-P330-P370+P378-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   0.9108
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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