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CS-W001157 4
Total: USD 88.00

5,6-Difluoroisoindoline hydrochloride

  • CAS No. 1820619-19-9

  • Cat. No. CS-0435138
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5,6-Difluoroisoindoline hydrochloride|CS-0435138

Structure of 1820619-19-9

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Description

5,6-Difluoroisoindoline hydrochloride offers a highly reactive, electron-deficient isoindoline scaffold ideal for coupling reactions. The difluorinated ring system enhances stability and modulates electronic properties, enabling efficient incorporation into complex molecular architectures under standard conditions.

Application

5,6-Difluoroisoindoline hydrochloride serves as a valuable building block for fluorinated heterocycles in medicinal chemistry. The difluoro substitution enhances metabolic stability and modulates electronic properties, while the hydrochloride salt improves solubility and handling. It functions reliably in Pd-catalyzed cross-coupling reactions and serves as a scaffold for constructing complex pharmaceutical intermediates under standard reaction conditions.

General Information

  • CAS No. 1820619-19-9
  • Cat. No. CS-0435138
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈ClF₂N
  • Molecular Weight 191.61
  • Synonym(s) None
  • SMILES FC1=C(F)C=C(CNC2)C2=C1.Cl

Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.9898
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P501

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