5-Chloro-2,4-difluoropyridine

Name: 5-Chloro-2,4-difluoropyridine
Brand: ChemScene
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CAS No. 1807257-52-8
Cat. No. CS-0514535
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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5-Chloro-2,4-difluoropyridine|CS-0514535

Structure of 1807257-52-8

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General Information

CAS No. 1807257-52-8
Cat. No. CS-0514535
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₂ClF₂N
Molecular Weight 149.53
Synonym(s) None
SMILES FC1=CC(F)=NC=C1Cl

Description

5-Chloro-2,4-difluoropyridine features a highly reactive pyridine core with strategically positioned halogen substituents. This electron-deficient heterocycle enables efficient cross-coupling and nucleophilic substitution under mild conditions. The orthogonal reactivity of chlorine and fluorine allows for sequential functionalization in complex molecule synthesis. Bench-stable and moisture-tolerant, it serves as a key building block in pharmaceutical and agrochemical development.

Application

5-Chloro-2,4-difluoropyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution. Its orthogonal reactivity allows selective functionalization at the C5 position while preserving fluorine handles for further derivatization. The compound exhibits excellent bench stability and compatibility with standard coupling protocols, facilitating integration into multi-step synthesis workflows for API development.

Safety Information

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GHS Pictogram :	GHS No : GHS02,GHS07
Signal Word : Danger	UN#: 1993
Class : 3	Packing Group : Ⅲ
Hazard Statements : H226-H302-H412
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P270-P273-P280-P330-P370+P378-P501

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Computational Chemistry Data

TPSA 12.89
LogP 2.0132
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

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5-Chloro-2,4-difluoropyridine

CAS No. 1807257-52-8

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