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CS-W001157 4
Total: USD 88.00

2-Fluoro-3,5-dichloropyridine

  • CAS No. 823-56-3

  • Cat. No. CS-W016070
  • Purity≥97%
  • MDL No.MFCD04039349

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-3,5-dichloropyridine|CS-W016070

Structure of 823-56-3

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General Information

  • CAS No. 823-56-3
  • Cat. No. CS-W016070
  • Purity ≥97%
  • MDL No. MFCD04039349
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂Cl₂FN
  • Molecular Weight 165.98
  • Synonym(s) 3,5-Dichloro-2-fluoropyridine
  • SMILES ClC1=CN=C(F)C(Cl)=C1

Description

For use as a matrix in MALDI mass spectrometry analysis

Application

2-Fluoro-3,5-dichloropyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of substituted pyridine scaffolds via nucleophilic aromatic substitution. Its orthogonal reactivity profile—where the fluorine acts as a selective displacement handle while the chlorines remain stable under mild conditions—facilitates sequential functionalization. The compound exhibits excellent bench stability and is compatible with common coupling protocols, making it ideal for modular synthesis of API intermediates and heterocyclic libraries.

Synthesis

  • Route1

    References

    • Bobbio, Carla; Schlosser, Manfred European Journal of Organic Chemistry, 2001 , # 23 p. 4533 - 4536
  • Route2
    • 3,5-Dichloropyridine Etoricoxib  Impurity|CS-0229442
      2457-47-8
    • ~45%
    • In-stock
      2-Fluoro-3,5-dichloropyridine|CS-W016070
      823-56-3

    References

    • Puy, Michael Van Der Tetrahedron Letters, 1987 , vol. 28, # 3 p. 255 - 258
  • Route3

    References

    • US5468863 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.5275
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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