Lot numbers can be found on the outside label of a product:
5-Chloro-2,3-difluoropyridine
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CAS No. 89402-43-7
- Cat. No. CS-W003144
- Purity≥95%
- MDL No.MFCD04039314
*For research and further manufacturing use only, not for direct human use.
Structure of 89402-43-7
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General Information
- CAS No. 89402-43-7
- Cat. No. CS-W003144
- Purity ≥95%
- MDL No. MFCD04039314
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₂ClF₂N
- Molecular Weight None
- Synonym(s) 2,3-Difuoro-5-chloropyridine
- SMILES FC1=CC(Cl)=CN=C1F
Description
5-Chloro-2,3-difluoropyridine is a fluorinated heterocycle featuring strategically positioned halogens enabling selective cross-coupling and electrophilic substitution. This electron-deficient pyridine derivative facilitates efficient C–H functionalization and serves as a key scaffold in agrochemical and pharmaceutical synthesis. The ortho-fluoro substituents enhance reactivity while maintaining stability under standard conditions.
Application
5-Chloro-2,3-difluoropyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling. Its orthogonal reactivity profile—driven by the electron-deficient pyridine ring and strategically positioned halogens—facilitates selective substitution under mild conditions. The molecule exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for constructing complex heterocyclic scaffolds in API development.
Synthesis
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Route1
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In-stock
103999-77-5 -
13400-13-0 - ~87%
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In-stock
89402-43-7
References
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Ciba Geigy Corporation Patent: US4713109 A1, 1987 ;
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Route2
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In-stock
16063-70-0 - ~%
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In-stock
89402-43-7
References
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Synthetic Communications, , vol. 34, # 23 p. 4301 - 4311
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Route3
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In-stock
103999-77-5
- ~75%
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In-stock
89402-43-7
References
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Differding, E.; Frick, W.; Lang, R. W.; Martin, P.; Schmit, C.; et al. Bulletin des Societes Chimiques Belges, 1990 , vol. 99, # 9 p. 647 - 671
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅲ
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Hazard Statements : H226-H302-H412
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Precautionary Statements : P210-P233-P240-P241-P273
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Quality Control
Computational Chemistry Data
- TPSA 12.89
- LogP 2.0132
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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