2-Bromo-6-fluoro-4-methylpyridine

Name: 2-Bromo-6-fluoro-4-methylpyridine
Brand: ChemScene
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CAS No. 180608-37-1
Cat. No. CS-0040664
Purity≥98%
MDL No.MFCD09839269

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Bromo-6-fluoro-4-methylpyridine|CS-0040664

Structure of 180608-37-1

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Description

2-Bromo-6-fluoro-4-methylpyridine features a strategically positioned bromine and fluorine substitution on a pyridine core, enabling selective cross-coupling reactions. The methyl group enhances electron density at C4, while the ortho-fluorine improves metabolic stability. This compound serves as a key intermediate in medicinal chemistry for constructing bioactive heterocycles under standard conditions.

Application

2-Bromo-6-fluoro-4-methylpyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromine site facilitates Suzuki, Negishi, and Buchwald–Hartwig couplings, while the fluorine and methyl groups provide orthogonal functionalization potential. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for constructing complex heterocyclic scaffolds in API development.

General Information

CAS No. 180608-37-1
Cat. No. CS-0040664
Purity ≥98%
MDL No. MFCD09839269
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅BrFN
Molecular Weight 190.01
Synonym(s) 2-Bromo-6-Fluoro-4-Picoline
SMILES CC1=CC(Br)=NC(F)=C1

Computational Chemistry Data

TPSA 12.89
LogP 2.29162
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-6-fluoro-4-methylpyridine

CAS No. 180608-37-1

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