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Structure of 1805519-87-2
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Methyl 6-chloro-2-(difluoromethoxy)nicotinate features a trifluoromethyl-like electronic profile due to the difluoromethoxy group, enhancing electrophilicity at the pyridine ring. This bench-stable ester integrates readily into synthetic sequences requiring electron-deficient heterocyclic scaffolds, particularly in medicinal chemistry and agrochemical lead optimization.
Methyl 6-chloro-2-(difluoromethoxy)nicotinate serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its trifunctionalized pyridine core—featuring a chloro group at C6, a difluoromethoxy substituent at C2, and a methyl ester at C1—offers orthogonal reactivity for cross-coupling, nucleophilic substitution, and selective reduction. The molecule exhibits excellent bench stability, facilitates straightforward purification, and functions effectively in standard synthetic workflows involving Pd-catalyzed transformations or electrophilic functionalization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: