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CS-W001157 4
Total: USD 88.00

(S)-4-Methyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole

  • CAS No. 1803416-27-4

  • Cat. No. CS-0610945
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-4-Methyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole|CS-0610945

Structure of 1803416-27-4

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General Information

  • CAS No. 1803416-27-4
  • Cat. No. CS-0610945
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉F₃N₂O
  • Molecular Weight 230.19
  • Synonym(s) None
  • SMILES C[C@@H]1N=C(C2=CC=C(C(F)(F)F)C=N2)OC1

Description

This chiral oxazole features a (S)-configured stereocenter and integrates a trifluoromethyl-substituted pyridine ring, enhancing electron deficiency and metabolic stability. The fused dihydrooxazole core provides rigidity and facilitates incorporation into complex heterocyclic scaffolds. Designed for medicinal chemistry applications, this building block enables efficient access to bioactive molecules through palladium-catalyzed cross-coupling and functionalization reactions under standard conditions.

Application

(S)-4-Methyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole serves as a versatile chiral building block in medicinal chemistry, enabling access to diverse heterocyclic scaffolds. Its pyridine-trifluoromethyl moiety enhances metabolic stability and modulates electronic properties, while the dihydrooxazole ring provides a reactive handle for selective transformations. Bench-stable and compatible with standard synthetic protocols, it facilitates efficient synthesis of complex targets through functional group interconversions and coupling reactions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   2.2657
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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