Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-[(4S)-4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-5-(trifluoromethyl)pyridine

  • CAS No. 1416819-91-4

  • Cat. No. CS-0086738
  • Purity≥97%
  • MDL No.MFCD23701103

*For research and further manufacturing use only, not for direct human use.

2-[(4S)-4-(1,1-Dimethylethyl)-4,5-dihydro-2-oxazolyl]-5-(trifluoromethyl)pyridine|CS-0086738

Structure of 1416819-91-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 1416819-91-4
  • Cat. No. CS-0086738
  • Purity ≥97%
  • MDL No. MFCD23701103
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₅F₃N₂O
  • Molecular Weight 272.27
  • Synonym(s) 2-[(4S)-4-tert-Butyl-4,5-dihydro-2-oxazolyl]-5-(trifluoromethyl)pyridine
  • SMILES CC(C)(C)[C@@H](CO1)N=C1C2=NC=C(C(F)(F)F)C=C2

Description

(S)-5-CF3-Pyox-tBu is a bench-stable, moisture-tolerant pyridine-based scaffold featuring a sterically hindered tert-butyl group and a strongly electron-withdrawing trifluoromethyl substituent at the 5-position. This configuration enhances regioselectivity in cross-coupling reactions and improves stability during handling and storage under standard conditions.

Application

(S)-5-CF₃-Pyox-tBu serves as a robust chiral building block for the synthesis of fluorinated heterocycles, leveraging its trifluoromethyl group and tert-butyl oxime handle to enable selective transformations. The stereogenic center ensures high enantioselectivity in downstream coupling reactions, while the pyox scaffold exhibits excellent bench stability and compatibility with standard purification methods. This compound facilitates efficient access to complex scaffolds relevant to medicinal chemistry campaigns requiring enhanced metabolic stability and membrane permeability.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   34.48
  • LogP   3.2919
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 1416819-91-4 sigma1416819-91-4 manufacturer1416819-91-4 price1416819-91-4 structure1416819-91-4 SDSbuy 1416819-91-41416819-91-4 supplier1416819-91-4 uses1416819-91-4 molecular weightprice of 1416819-91-41416819-91-4 chemical name formula of 1416819-91-4
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label