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CS-W001157 4
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(S)-4-Methyl-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole

  • CAS No. 1416820-33-1

  • Cat. No. CS-0610828
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-4-Methyl-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole|CS-0610828

Structure of 1416820-33-1

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General Information

  • CAS No. 1416820-33-1
  • Cat. No. CS-0610828
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉F₃N₂O
  • Molecular Weight 230.19
  • Synonym(s) None
  • SMILES C[C@@H](CO1)N=C1C2=CC(C(F)(F)F)=CC=N2

Description

(S)-4-Methyl-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole is a chiral heterocyclic scaffold featuring a trifluoromethyl-pyridine moiety and a stereodefined oxazole ring. This configuration imparts enhanced metabolic stability and favorable binding affinity in targeted small-molecule applications. The molecule integrates readily into medicinal chemistry campaigns requiring electron-deficient aromatic systems with controlled stereochemistry.

Application

(S)-4-Methyl-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole serves as a versatile chiral building block for the synthesis of bioactive heterocycles. Its structural motif combines a pyridine-fused oxazole with a stereogenic center, enabling efficient access to complex scaffolds via transition-metal-catalyzed couplings and functional group interconversions. The molecule exhibits good bench stability and facilitates orthogonal reactivity in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   34.48
  • LogP   2.2657
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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