Phenyltris(dimethylsiloxy)silane

Name: Phenyltris(dimethylsiloxy)silane
Brand: ChemScene
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CAS No. 18027-45-7
Cat. No. CS-0158125
Purity≥97%
MDL No.MFCD00053849

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Phenyltris(dimethylsiloxy)silane|CS-0158125

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General Information

CAS No. 18027-45-7
Cat. No. CS-0158125
Purity ≥97%
MDL No. MFCD00053849
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₆O₃Si₄
Molecular Weight 330.68
Synonym(s) Tris(dimethylsilyloxy)phenylsilane
SMILES C[SiH](C)O[Si](C1=CC=CC=C1)(O[SiH](C)C)O[SiH](C)C

Description

Phenyltris(dimethylsiloxy)silane serves as a stable, moisture-tolerant silylating agent featuring a phenyl group and three dimethylsiloxy substituents. This bulky, bench-stable reagent facilitates selective protection of alcohols and amines in complex molecular architectures. The silicon center enables efficient coupling under mild conditions, while the electron-donating siloxy groups enhance reactivity without compromising handling safety.

Application

Phenyltris(dimethylsiloxy)silane serves as a stable, bench-ready silyl transfer reagent enabling efficient protection of alcohols and selective silylation of sensitive functional groups. Its high functional group tolerance and compatibility with standard reaction conditions facilitate reliable downstream transformations in complex molecule synthesis. The trimethylsilyl-like reactivity profile is achieved without the volatility or moisture sensitivity associated with traditional TMS reagents, making it ideal for scalable, reproducible protocols in medicinal chemistry and process development.

Synthesis

Route1
- 3277-26-7
- 2996-92-1
- ~%
- In-stock
  
  18027-45-7
References
- US2012/46485 A1, ; Page/Page column 5 ;
Route2
- 1066-35-9
- 98-13-5
- ~%
- In-stock
  
  18027-45-7
References
- US2877255 , ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P210-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P403-P405-P501

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Computational Chemistry Data

TPSA 27.69
LogP 1.8325
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 7

Other Classifications

General Reagents Reductive Reagents Silane Reductive Reagents

Material Science Organic-Inorganic Hybrid Materials A silane coupling agent

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Chemical Synthesis Organometallic Reagents Organosilicon Siloxanes

Chemical Synthesis Organometallic Reagents Organosilicon Trialkoxysilanes

Chemical Synthesis Organometallic Reagents Organosilicon Hydrosilanes

Chemical Synthesis Synthetic Reagents Reduction Silanes

Key Words

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Phenyltris(dimethylsiloxy)silane

CAS No. 18027-45-7

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