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CS-W001157 4
Total: USD 88.00

2-Chloro-3-fluoro-5-iodopyridin-4-amine

  • CAS No. 1801841-62-2

  • Cat. No. CS-0167775
  • Purity≥95%
  • MDL No.MFCD31672865

*For research and further manufacturing use only, not for direct human use.

2-Chloro-3-fluoro-5-iodopyridin-4-amine|CS-0167775

Structure of 1801841-62-2

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General Information

  • CAS No. 1801841-62-2
  • Cat. No. CS-0167775
  • Purity ≥95%
  • MDL No. MFCD31672865
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFIN₂
  • Molecular Weight 272.45
  • Synonym(s) None
  • SMILES NC1=C(F)C(Cl)=NC=C1I

Description

2-Chloro-3-fluoro-5-iodopyridin-4-amine features a trihalogenated pyridine core with strategically positioned electron-withdrawing substituents, enabling selective cross-coupling reactions. This bench-stable scaffold integrates readily into complex heterocycles under standard conditions, serving as a key intermediate in the synthesis of bioactive pharmaceuticals and functional materials.

Application

2-Chloro-3-fluoro-5-iodopyridin-4-amine serves as a versatile building block for constructing substituted pyridine scaffolds in medicinal chemistry. Its orthogonal halogenation pattern enables sequential cross-coupling reactions, facilitating the assembly of complex heterocycles. The compound exhibits good bench stability and compatibility with palladium-catalyzed transformations, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.0609
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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