2,6-Dichloro-3-fluoropyridin-4-amine

Name: 2,6-Dichloro-3-fluoropyridin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 2051921-49-2
Cat. No. CS-0568464
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,6-Dichloro-3-fluoropyridin-4-amine|CS-0568464

Structure of 2051921-49-2

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General Information

CAS No. 2051921-49-2
Cat. No. CS-0568464
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃Cl₂FN₂
Molecular Weight 181.00
Synonym(s) None
SMILES NC1=C(F)C(Cl)=NC(Cl)=C1

Description

2,6-Dichloro-3-fluoropyridin-4-amine features a pyridine core functionalized with chlorine and fluorine substituents at electron-deficient positions, enabling high reactivity in cross-coupling and nucleophilic substitution reactions. The para-chloro groups facilitate palladium-catalyzed coupling, while the fluorine enhances electrophilicity. This compound serves as a key building block in pharmaceutical synthesis due to its stability and compatibility with diverse reaction conditions.

Application

2,6-Dichloro-3-fluoropyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its orthogonal reactivity profile—driven by the electron-deficient pyridine core and strategically positioned halogen atoms—facilitates sequential functionalization. The compound exhibits excellent bench stability and compatibility with common protecting groups, making it well-suited for multi-step synthesis and API development workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 2.1097
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Drug Discovery Cancer KRAS

Key Words

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2,6-Dichloro-3-fluoropyridin-4-amine

CAS No. 2051921-49-2

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