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CS-W001157 4
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5-Bromo-6-methoxy-1H-indole

  • CAS No. 177360-11-1

  • Cat. No. CS-0139595
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Bromo-6-methoxy-1H-indole|CS-0139595

Structure of 177360-11-1

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General Information

  • CAS No. 177360-11-1
  • Cat. No. CS-0139595
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈BrNO
  • Molecular Weight 226.07
  • Synonym(s) 1H-Indole, 5-broMo-6-Methoxy-
  • SMILES COC1=CC2=C(C=C1Br)C=CN2

Description

5-Bromo-6-methoxy-1H-indole features a brominated indole core with a methoxy group at the 6-position, enhancing solubility and electronic modulation. This bench-stable heterocycle integrates readily into synthetic routes for bioactive molecules, offering predictable reactivity in cross-coupling and functionalization processes.

Application

5-Bromo-6-methoxy-1H-indole serves as a valuable building block for the synthesis of biologically active heterocycles and pharmaceutical intermediates. The bromo group enables palladium-catalyzed cross-coupling reactions, while the methoxy substituent provides electronic modulation and orthogonality in multi-step syntheses. This compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable medicinal chemistry campaigns and API development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

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Computational Chemistry Data

  • TPSA   25.02
  • LogP   2.939
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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