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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-methoxypyridine

  • CAS No. 175965-83-0

  • Cat. No. CS-W006693
  • Purity≥97%
  • MDL No.MFCD12828014

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-methoxypyridine|CS-W006693

Structure of 175965-83-0

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General Information

  • CAS No. 175965-83-0
  • Cat. No. CS-W006693
  • Purity ≥97%
  • MDL No. MFCD12828014
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆FNO
  • Molecular Weight 127.12
  • Synonym(s) Pyridine, 2-fluoro-4-methoxy- (9CI)
  • SMILES COC1=CC(F)=NC=C1

Description

2-Fluoro-4-methoxypyridine is a bench-stable heterocyclic building block featuring a fluorine atom at the 2-position and a methoxy group at the 4-position. This electron-deficient pyridine scaffold enables efficient coupling reactions, particularly in palladium-catalyzed cross-couplings, where the ortho-fluorine facilitates selective functionalization. Its moisture-tolerant nature simplifies handling under standard laboratory conditions.

Application

2-Fluoro-4-methoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its ortho-fluoro substituent facilitates nucleophilic substitution under mild conditions, while the para-methoxy group enhances solubility and modulates electronic properties. The compound exhibits excellent bench stability and compatibility with diverse reaction conditions, making it ideal for constructing heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   1.2293
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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