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CS-W001157 4
Total: USD 88.00

2-Fluoropyridin-4-ol

  • CAS No. 22282-69-5

  • Cat. No. CS-W019270
  • Molecule weight113.09
  • Purity≥98%
  • MDL No.MFCD04114159

*For research and further manufacturing use only, not for direct human use.

2-Fluoropyridin-4-ol|CS-W019270

Structure of 22282-69-5

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General Information

  • CAS No. 22282-69-5
  • Cat. No. CS-W019270
  • Purity ≥98%
  • MDL No. MFCD04114159
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄FNO
  • Molecular Weight 113.09
  • Synonym(s) 2-Fluoro-4-Hydroxypyridine
  • SMILES FC1=NC=CC(=C1)O

Description

2-Fluoropyridin-4-ol features a fluorine atom at the 2-position and a hydroxyl group at the 4-position on a pyridine ring, creating a polar, electron-deficient heterocycle. This arrangement enables direct functionalization at the 3- or 5-position, facilitating coupling reactions under mild conditions. The compound exhibits enhanced stability compared to analogous phenols and serves as a key building block in medicinal chemistry for kinase inhibitors and fluorescent probes.

Application

2-Fluoropyridin-4-ol serves as a versatile building block for constructing fluorinated heterocycles and bioactive molecules. Its reactivity enables direct nucleophilic substitution at the C2 position, facilitating the synthesis of substituted pyridines under mild conditions. The hydroxyl group offers orthogonal handling for derivatization, while the fluorine substituent enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with standard synthetic workflows, it functions effectively in coupling reactions and scaffold elaboration for medicinal chemistry applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   0.9263
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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