2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine

Name: 2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine
Brand: ChemScene
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CAS No. 175277-67-5
Cat. No. CS-0098658
Molecule weight231.00
Purity≥97%
MDL No.MFCD00173957

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine|CS-0098658

Structure of 175277-67-5

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General Information

CAS No. 175277-67-5
Cat. No. CS-0098658
Purity ≥97%
MDL No. MFCD00173957
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃Cl₂F₃N₂
Molecular Weight 231.00
Synonym(s) 3-Amino-2,6-dichloro-4-(trifluoromethyl)-pyridine
SMILES NC1=C(C(F)(F)F)C=C(Cl)N=C1Cl

Description

2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine features a trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the dichloro substitution pattern enables selective coupling in late-stage functionalization. This pyridine scaffold serves as a key building block for bioactive heterocycles in medicinal chemistry.

Application

2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to diverse heterocyclic scaffolds. The dichloro substitution pattern facilitates sequential cross-coupling reactions, while the trifluoromethyl group enhances metabolic stability and lipophilicity. Its amine functionality provides a direct handle for derivatization via amidation, alkylation, or reductive amination, offering high compatibility with standard synthetic workflows. The compound exhibits excellent bench stability and ease of purification, making it well-suited for both exploratory and process-scale applications.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 38.91
LogP 2.9894
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Dichloro-4-(trifluoromethyl)pyridin-3-amine

CAS No. 175277-67-5

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