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CS-W001157 4
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5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

  • CAS No. 1337532-51-0

  • Cat. No. CS-W010419
  • Molecule weight227.07
  • Purity≥97%
  • MDL No.MFCD20486185

*For research and further manufacturing use only, not for direct human use.

5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine|CS-W010419

Structure of 1337532-51-0

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General Information

  • CAS No. 1337532-51-0
  • Cat. No. CS-W010419
  • Purity ≥97%
  • MDL No. MFCD20486185
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇BrN₄
  • Molecular Weight 227.07
  • Synonym(s) 6-Amino-7-bromo-9-methyl-7-deazapurine
  • SMILES NC1=C2C(N(C)C=C2Br)=NC=N1

Description

Biotin-PEG7-thiourea is reactive with amine-containing macromolecule. The hydrophilic PEG arm improves water solubility. The biotin groups serve as an affinity label towards the proteins avidin and streptavidin. The thiourea group can be used as a source of sulfide, such as for converting alkyl halides to thiols.

Synthesis

  • Route1
    • In-stock
      5-Bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine|CS-0098087
      1266343-30-9
    • ~77%
    • In-stock
      5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine|CS-W010419
      1337532-51-0

    References

    • Axten, Jeffrey M.; Medina, Jesus R.; Feng, Yanhong; Shu, Arthur; Romeril, Stuart P.; Grant, Seth W.; Li, William Hoi Hong; Heerding, Dirk A.; Minthorn, Elisabeth; Mencken, Thomas; Atkins, Charity; Liu, Qi; Rabindran, Sridhar; Kumar, Rakesh; Hong, Xuan; Goetz, Aaron; Stanley, Thomas; Taylor, J. David; Sigethy, Scott D.; Tomberlin, Ginger H.; Hassell, Annie M.; Kahler, Kirsten M.; Shewchuk, Lisa M.; Gampe, Robert T. Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7193 - 7207
  • Route2

    References

    • WO2011/119663 A1, ; WO 2011/119663 A1
  • Route3
    • 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Tofacitinib Impurity|CS-0213936
      3680-69-1
    • ~%
    • In-stock
      5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine|CS-W010419
      1337532-51-0

    References

    • WO2011/119663 A1, ; WO 2011/119663 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   56.73
  • LogP   1.313
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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