2,6-Dimethoxypyridin-4-amine

Name: 2,6-Dimethoxypyridin-4-amine
Brand: ChemScene
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CAS No. 17325-39-2
Cat. No. CS-0036587
Purity≥95%
MDL No.None

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 17325-39-2

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General Information

CAS No. 17325-39-2
Cat. No. CS-0036587
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀N₂O₂
Molecular Weight 154.17
Synonym(s) 4-Amino-2,6-dimethoxypyridine
SMILES COC1=NC(=CC(=C1)N)OC

Description

2,6-Dimethoxypyridin-4-amine features a pyridine core functionalized with two methoxy groups and a primary amine at the 4-position. This electron-rich scaffold offers enhanced solubility and stability under standard conditions, enabling efficient incorporation into medicinal chemistry libraries. The para-amino group facilitates direct coupling reactions for building complex heterocyclic architectures.

Application

2,6-Dimethoxypyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its two methoxy groups enhance solubility and modulate electronic properties, while the primary amine facilitates derivatization. The compound exhibits bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis workflows in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS06,GHS09
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H300-H315-H319-H335-H411
Precautionary Statements : P261-P264-P330

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Computational Chemistry Data

TPSA 57.37
LogP 0.681
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2,6-Dimethoxypyridin-4-amine

CAS No. 17325-39-2

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