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CS-W001157 4
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Methyl 2,3-dibromopropanoate

  • CAS No. 1729-67-5

  • Cat. No. CS-0187461
  • Purity≥98%
  • MDL No.MFCD00017882

*For research and further manufacturing use only, not for direct human use.

Methyl 2,3-dibromopropanoate|CS-0187461

Structure of 1729-67-5

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General Information

  • CAS No. 1729-67-5
  • Cat. No. CS-0187461
  • Purity ≥98%
  • MDL No. MFCD00017882
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆Br₂O₂
  • Molecular Weight 245.90
  • Synonym(s) Propionic acid, 2,3-dibromo-, methyl ester (8CI)
  • SMILES COC(=O)C(CBr)Br

Description

Methyl 2,3-dibromopropanoate features a dibromo-substituted aliphatic chain that enables selective functionalization in synthetic routes. This reagent integrates readily into carbon–carbon bond-forming processes, offering high reactivity under mild conditions. The ester functionality provides solubility and handles well in standard organic workflows.

Application

Methyl 2,3-dibromopropanoate serves as a versatile dihalogenated building block for the synthesis of β-halo esters and functionalized heterocycles. Its well-defined reactivity enables selective nucleophilic substitution and elimination reactions, facilitating access to α,β-unsaturated esters and cyclic ethers under mild conditions. The compound exhibits excellent bench stability and is compatible with common protecting group strategies, making it a reliable intermediate in complex molecule assembly.

Synthesis

  • Route1
    • null|null
      292638-85-8
    • ~10%
    • In-stock
      Methyl 2,3-dibromopropanoate|CS-0187461
      1729-67-5

    References

    • Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C. Tetrahedron Asymmetry, 2012 , vol. 23, # 22-23 p. 1615 - 1623
  • Route2
    • null|null
      67-56-1
    • null|null
      600-05-5
    • ~%
    • In-stock
      Methyl 2,3-dibromopropanoate|CS-0187461
      1729-67-5

    References

    • Anales de la Asociacion Quimica Argentina (1921-2001), vol. 16, p. 50 Chem. Zentralbl., , vol. 99, # II p. 2548
  • Route3
    • null|null
      292638-85-8
    • ~%
    • In-stock
      Methyl 2,3-dibromopropanoate|CS-0187461
      1729-67-5
    • In-stock
      Methyl 2-bromo-3-hydroxypropanoate|CS-0187469
      7691-28-3
    • null|null
      32777-05-2

    References

    • Bulletin of the Chemical Society of Japan, , vol. 57, # 5 p. 1394 - 1400

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P264-P270-P271-P280-P304+P340-P330-P331-P363-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.3178
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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