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Methyl 2-bromo-3-fluoropropanoate

  • CAS No. 1537-52-6

  • Cat. No. CS-0312102
  • Molecule weight184.99
  • Purity≥98%
  • MDL No.MFCD09800641

*For research and further manufacturing use only, not for direct human use.

Methyl 2-bromo-3-fluoropropanoate|CS-0312102

Structure of 1537-52-6

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General Information

  • CAS No. 1537-52-6
  • Cat. No. CS-0312102
  • Purity ≥98%
  • MDL No. MFCD09800641
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₆BrFO₂
  • Molecular Weight 184.99
  • Synonym(s) 2-Bromo-3-fluoropropionic acid methyl ester
  • SMILES O=C(OC)C(Br)CF

Description

Azido-PEG6-PFP ester is a a high purity PEG linker containing azide and PFP ester moities. The azide can participate in Click Chemistry reactions with alkynes, such as DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester.

Synthesis

  • Route1

    References

    • Gerus, I. I.; Yagupol'skii, Yu. L.; Kukhar, V. P.; Boguslavskaya, L. S.; Chuvatkin, N. N.; et al. Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 3.1 p. 465 - 468 Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 3 p. 537 - 541
  • Route2
    • null|null
      292638-85-8
    • ~51%
    • null|null
      399-86-0
    • Methyl 2-bromo-3-fluoropropanoate|CS-0312102
      1537-52-6

    References

    • Boguslavskaya, L. S.; Chuvatkin, N. N.; Kartashov, A. V.; Ternovskoi, L. A. Journal of Organic Chemistry USSR (English Translation), 1987 , vol. 23, p. 230 - 236 Zhurnal Organicheskoi Khimii, 1987 , vol. 23, # 2 p. 262 - 269
  • Route3

    References

    • Kartashov, A. V.; Chuvatkin, N. N.; Boguslavskaya, L. S. Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 12.1 p. 2243 - 2248 Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 12 p. 2522 - 2528

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   0.8924
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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