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trans-3-((Benzyloxy)methyl)cyclobutanol

  • CAS No. 172324-65-1

  • Cat. No. CS-0040800
  • Molecule weight192.25
  • Purity≥97%
  • MDL No.MFCD06657677

*For research and further manufacturing use only, not for direct human use.

trans-3-((Benzyloxy)methyl)cyclobutanol|CS-0040800

Structure of 172324-65-1

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General Information

  • CAS No. 172324-65-1
  • Cat. No. CS-0040800
  • Purity ≥97%
  • MDL No. MFCD06657677
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆O₂
  • Molecular Weight 192.25
  • Synonym(s) TRANS-3-BENZYLOXYMETHYLCYCLOBUTANOL
  • SMILES O[C@H]1C[C@H](COCC2=CC=CC=C2)C1

Description

Pomalidomide-PEG3-C2-NH2 contains a cereblon ligand, a PEG linker, an alkylC2 chain, and a terminal amine. This product is ready for conjugation to target proteins for PROTAC R&D.

Synthesis

  • Route1

    References

    • Kaiwar, Vijay; Reese, Colin B.; Gray, Emily J.; Neidle, Stephen Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 18 p. 2281 - 2288
  • Route2

    References

    • PFIZER LIMITED Patent: WO2006/92691 A1, 2006 ; Location in patent: Page/Page column 78 ;
  • Route3
    • cis-3-[(Benzyloxy)methyl]cyclobutanol|CS-0040837
      172324-68-4
    • ~%
    • trans-3-((Benzyloxy)methyl)cyclobutanol|CS-0040800
      172324-65-1

    References

    • Kaiwar, Vijay; Reese, Colin B.; Gray, Emily J.; Neidle, Stephen Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 18 p. 2281 - 2288

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.9741
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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