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Structure of 170856-87-8
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4-(Piperazin-1-yl)benzenesulfonamide features a sulfonamide group linked to a para-substituted phenyl ring, enabling strong hydrogen bonding and enhanced solubility. The piperazine moiety imparts metabolic stability and facilitates salt formation, making this scaffold valuable in medicinal chemistry for kinase inhibitors and antibacterial agents.
4-(Piperazin-1-yl)benzenesulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of sulfonamide-containing heterocycles and bioactive scaffolds. Its piperazine moiety provides enhanced solubility and hydrogen-bonding capacity, while the sulfonamide group offers strong polarity and metabolic stability. The compound exhibits bench stability, facilitates purification via crystallization, and participates reliably in standard coupling reactions, making it well-suited for lead optimization and API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H315-H319-H332-H335
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Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P341-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: