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CS-W001157 4
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m-PEG3-CH2COOH

  • CAS No. 16024-60-5

  • Cat. No. CS-0107949
  • Purity≥96%
  • MDL No.MFCD25959645

*For research and further manufacturing use only, not for direct human use.

m-PEG3-CH2COOH|CS-0107949

Structure of 16024-60-5

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General Information

  • CAS No. 16024-60-5
  • Cat. No. CS-0107949
  • Purity ≥96%
  • MDL No. MFCD25959645
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈O₆
  • Molecular Weight 222.24
  • Synonym(s) None
  • SMILES OC(COCCOCCOCCOC)=O

Description

m-PEG3-CH2COOH features a methoxy-terminated PEG3 spacer linking a reactive carboxylic acid group, enabling efficient conjugation in bioconjugation workflows. This derivative combines excellent solubility with stable handling under standard conditions, facilitating integration into peptide and protein labeling strategies.

Application

m-PEG3-CH2COOH serves as a versatile bifunctional linker for conjugation and polymer synthesis, combining the stability of a methoxy-terminated PEG chain with a reactive carboxylic acid group. It facilitates efficient amide bond formation under standard coupling conditions, enabling site-specific modification of peptides, proteins, and biomolecules. The PEG spacer provides enhanced solubility and reduced non-specific binding in biological applications.

Synthesis

  • Route1
    • null|null
      186429-53-8
    • ~%
    • In-stock
      m-PEG3-CH2COOH|CS-0107949
      16024-60-5

    References

    • ISIS PHARMACEUTICALS, INC.; BUCHARDT, Dorte; NIELSEN, Peter Eigil; EGHOLM, Michael Patent: EP804456 B1, 2002 ;
  • Route2
    • In-stock
      m-PEG3-OH|CS-0114074
      112-35-6
    • null|null
      79-11-8
    • ~82%
    • In-stock
      m-PEG3-CH2COOH|CS-0107949
      16024-60-5

    References

    • Zech, Oliver; Kellermeier, Matthias; Thomaier, Stefan; Maurer, Eva; Klein, Regina; Schreiner, Christian; Kunz, Werner Chemistry - A European Journal, 2009 , vol. 15, # 6 p. 1341 - 1345
  • Route3
    • null|null
      1197192-17-8
    • ~30%
    • In-stock
      m-PEG3-CH2COOH|CS-0107949
      16024-60-5

    References

    • Rerat, Vincent; Dive, Georges; Cordi, Alex A.; Tucker, Gordon C.; Bareille, Reine; Amedee, Joelle; Bordenave, Laurence; Marchand-Brynaert, Jacqueline Journal of Medicinal Chemistry, 2009 , vol. 52, # 22 p. 7029 - 7043

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   74.22
  • LogP   -0.2328
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   11

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