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CS-W001157 4
Total: USD 88.00

m-PEG4-CH2COOH

  • CAS No. 16024-66-1

  • Cat. No. CS-0108211
  • Purity≥98%
  • MDL No.MFCD00021759

*For research and further manufacturing use only, not for direct human use.

m-PEG4-CH2COOH|CS-0108211

Structure of 16024-66-1

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General Information

  • CAS No. 16024-66-1
  • Cat. No. CS-0108211
  • Purity ≥98%
  • MDL No. MFCD00021759
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂O₇
  • Molecular Weight 266.29
  • Synonym(s) None
  • SMILES COCCOCCOCCOCCOCC(O)=O

Description

m-PEG4-CH2COOH features a methoxy-terminated PEG chain of four ethylene oxide units linked to a methylene carboxylic acid group. This structure delivers enhanced solubility in aqueous and organic media, enabling efficient conjugation workflows. The terminal carboxylate facilitates direct coupling to primary amines under standard activation conditions.

Application

m-PEG4-CH2COOH serves as a versatile bifunctional linker for conjugation and polymer synthesis, combining the stability of a methoxy-terminated PEG chain with a reactive carboxylic acid group. It facilitates efficient coupling to amine-containing biomolecules or resins under standard EDC/NHS conditions, enabling controlled spacing in bioconjugates and functionalized surfaces. The PEG4 spacer provides enhanced solubility and reduced non-specific binding in aqueous environments, making it ideal for applications in medicinal chemistry, diagnostic labeling, and materials science.

Synthesis

  • Route1

    References

    • Heimann, Ulrich; Voegtle, Fritz Liebigs Annalen der Chemie, 1980 , # 6 p. 858 - 862
  • Route2
    • Tetraethylene glycol monomethyl ether HQ|CS-1347367
      23783-42-8
    • null|null
      79-08-3
    • ~%
    • In-stock
      m-PEG4-CH2COOH|CS-0108211
      16024-66-1

    References

    • Tuchscherer; Schaarschmidt; Schulze; Hietschold; Lang Dalton Transactions, 2012 , vol. 41, # 9 p. 2738 - 2746
  • Route3

    References

    • Heimann, Ulrich; Voegtle, Fritz Liebigs Annalen der Chemie, 1980 , # 6 p. 858 - 862

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   83.45
  • LogP   -0.2162
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   14

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