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CS-W001157 4
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4-Chloro-2-cyclopropyl-7-fluoroquinazoline

  • CAS No. 1699190-56-1

  • Cat. No. CS-0160861
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-cyclopropyl-7-fluoroquinazoline|CS-0160861

Structure of 1699190-56-1

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General Information

  • CAS No. 1699190-56-1
  • Cat. No. CS-0160861
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₈ClFN₂
  • Molecular Weight 222.65
  • Synonym(s) None
  • SMILES FC1=CC2=NC(C3CC3)=NC(Cl)=C2C=C1

Description

4-Chloro-2-cyclopropyl-7-fluoroquinazoline features a fused heterocyclic core with strategically positioned halogen and cyclopropyl substituents, enhancing electron-deficient character and metabolic stability. This scaffold integrates readily into kinase inhibitor libraries, offering improved binding affinity and solubility profiles in medicinal chemistry campaigns.

Application

4-Chloro-2-cyclopropyl-7-fluoroquinazoline serves as a versatile building block in medicinal chemistry, enabling efficient construction of kinase inhibitor scaffolds. Its orthogonal functional groups facilitate palladium-catalyzed cross-coupling reactions and nucleophilic substitution, with the cyclopropyl and fluoro substituents enhancing metabolic stability and target binding affinity. The compound exhibits excellent bench stability and ease of purification, making it well-suited for high-throughput synthesis and process-scale applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   3.2997
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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