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CS-W001157 4
Total: USD 88.00

2,6-Difluoropyridin-3-amine

  • CAS No. 108118-69-0

  • Cat. No. CS-0091201
  • Purity≥98%
  • MDL No.MFCD13185331

*For research and further manufacturing use only, not for direct human use.

2,6-Difluoropyridin-3-amine|CS-0091201

Structure of 108118-69-0

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General Information

  • CAS No. 108118-69-0
  • Cat. No. CS-0091201
  • Purity ≥98%
  • MDL No. MFCD13185331
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄F₂N₂
  • Molecular Weight 130.10
  • Synonym(s) 3-Pyridinamine,2,6-difluoro-(9CI)
  • SMILES NC1=CC=C(F)N=C1F

Description

2,6-Difluoropyridin-3-amine delivers a strategically positioned electron-deficient pyridine core with two fluorine substituents that enhance metabolic stability and modulate reactivity. This bench-stable amine integrates readily into pharmaceutical scaffolds, enabling efficient coupling reactions under mild conditions. The para-fluorinated arrangement supports directed functionalization and improves membrane permeability in bioactive molecules.

Application

2,6-Difluoropyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring via nucleophilic substitution due to the activating influence of the amine and the electron-withdrawing fluorine substituents. Its bench-stable nature, compatibility with standard coupling reactions, and utility in constructing heterocyclic scaffolds make it a practical choice for synthesizing kinase inhibitors and other bioactive molecules.

Synthesis

  • Route1
    • In-stock
      2,6-difluoro-3-nitropyridine|CS-W000551
      58602-02-1
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      7439-89-6
    • ~%
    • In-stock
      2,6-Difluoropyridin-3-amine|CS-0091201
      108118-69-0

    References

    • Eisai RandD Management Co., Ltd. Patent: EP2181992 A1, 2010 ;
  • Route2

    References

    • Radl, Stanislav; Hradil, Pavel Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 11.1 p. 2420 - 2429
  • Route3

    References

    • Radl, Stanislav; Hradil, Pavel Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 11.1 p. 2420 - 2429

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.942
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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