Lot numbers can be found on the outside label of a product:
2-Hydroxy-4-iodobenzoic acid
-
CAS No. 16870-28-3
- Cat. No. CS-0103689
- Purity≥98%
- MDL No.MFCD00061127
*For research and further manufacturing use only, not for direct human use.
Structure of 16870-28-3
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 16870-28-3
- Cat. No. CS-0103689
- Purity ≥98%
- MDL No. MFCD00061127
- Storage 4°C, protect from light, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₅IO₃
- Molecular Weight 264.02
- Synonym(s) 4-iodosalicylic acid
- SMILES O=C(O)C1=CC=C(I)C=C1O
Description
2-Hydroxy-4-iodobenzoic acid features a hydroxyl group ortho to the carboxylic acid and an iodine substituent at the para position, enabling selective functionalization in cross-coupling reactions. The electron-withdrawing iodide enhances reactivity while the adjacent hydroxyl supports hydrogen bonding and solubility in polar solvents. This combination delivers robust performance in synthetic intermediates for pharmaceuticals and advanced materials.
Application
2-Hydroxy-4-iodobenzoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to biaryl and heteroaryl architectures. The ortho-hydroxyl group provides enhanced solubility and facilitates directed metalation, while the iodide acts as a reliable coupling handle under standard Suzuki, Stille, or Negishi conditions. Bench-stable and readily purified by recrystallization, it functions effectively in late-stage functionalization workflows and synthetic routes to pharmaceutical intermediates.
Synthesis
-
Route1
-
65-49-6 - ~85%
-
In-stock
16870-28-3
References
-
PTC THERAPEUTICS, INC.; HWANG, Peter Seongwoo; TAKASUGI, James; REN, Hongyu; WILDE, Richard Gerald; TURPOFF, Anthony; AREFOLOV, Alexander; KARP, Gary Mitchell; CHEN, Guangming; CAMPBELL, Jeffrey Allen Patent: WO2006/19831 A1, 2006 ; Location in patent: Page/Page column 445 ;
-
-
Route2
-
In-stock
18179-39-0 - ~90%
-
In-stock
16870-28-3
References
-
Galderma Research and Development S.N.C. Patent: US6689922 B1, 2004 ; Location in patent: Page column 30 ;
-
-
Route3
-
In-stock
38170-02-4 - ~49%
-
In-stock
16870-28-3
References
-
Kuroda, Chiaki; Ochi, Atsushi; Nakane, Noritoshi; Umeyama, Takashi; Muto, Nobuko; Niimura, Nami; Teramoto, Yoshiki; Nogami, Hiroyuki; Reddy, Guvvala N. Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 2 p. 417 - 422
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS05,GHS06
|
|
Signal Word : Danger
|
UN#: 2811
|
|
Class : 6.1
|
Packing Group : Ⅲ
|
|
Hazard Statements : H301-H318-H412
|
|
|
Precautionary Statements : P264-P270-P273-P280-P330-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 57.53
- LogP 1.695
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 2-Hydroxy-4-iodobenzoic acid sigma2-Hydroxy-4-iodobenzoic acid manufacturer2-Hydroxy-4-iodobenzoic acid price2-Hydroxy-4-iodobenzoic acid structure2-Hydroxy-4-iodobenzoic acid SDSbuy 2-Hydroxy-4-iodobenzoic acid2-Hydroxy-4-iodobenzoic acid supplier2-Hydroxy-4-iodobenzoic acid uses2-Hydroxy-4-iodobenzoic acid molecular weightprice of 2-Hydroxy-4-iodobenzoic acid2-Hydroxy-4-iodobenzoic acid chemical name formula of 2-Hydroxy-4-iodobenzoic acid