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CS-W001157 4
Total: USD 88.00

1-Methylindole-7-carboxylic acid

  • CAS No. 167479-16-5

  • Cat. No. CS-0038765
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methylindole-7-carboxylic acid|CS-0038765

Structure of 167479-16-5

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General Information

  • CAS No. 167479-16-5
  • Cat. No. CS-0038765
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉NO₂
  • Molecular Weight 175.18
  • Synonym(s) 1-methyl-1H-indole-7-carboxylic acid
  • SMILES CN1C=CC2=C1C(=CC=C2)C(=O)O

Description

1-Methylindole-7-carboxylic acid features a sterically accessible carboxyl group appended to the indole core, enabling direct conjugation in bioconjugation workflows. The methyl substitution enhances metabolic stability and modulates electronic properties, making this scaffold valuable for designing targeted therapeutics and fluorescent probes.

Application

1-Methylindole-7-carboxylic acid serves as a versatile building block for indole-based pharmaceutical scaffolds, enabling efficient derivatization at the carboxylic acid group. Its bench-stable nature and compatibility with standard coupling protocols facilitate straightforward amide, ester, and acyl chloride formation. The molecule functions effectively in peptide synthesis and heterocyclic extensions, offering predictable reactivity and excellent functional group tolerance in medicinal chemistry workflows.

Synthesis

  • Route1

    References

    • Heterocycles, , vol. 67, # 2 p. 643 - 653
  • Route2
    • null|null
      167479-20-1
    • ~47%
    • In-stock
      1-Methylindole-7-carboxylic acid|CS-0038765
      167479-16-5

    References

    • Kitano, Masafumi; Kojima, Atsuyuki; Nakano, Kazuhiro; Miyagishi, Akira; Noguchi, Tsuyoshi; Ohashi, Naohito Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 11 p. 1538 - 1548
  • Route3
    • null|null
      208772-25-2
    • ~%
    • In-stock
      1-Methylindole-7-carboxylic acid|CS-0038765
      167479-16-5

    References

    • US6372764 B1, ; US 6372764 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   42.23
  • LogP   1.8765
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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