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CS-W001157 4
Total: USD 88.00

1-(Tert-butoxycarbonyl)-4-phenylpiperidine-4-carboxylic acid

  • CAS No. 167262-68-2

  • Cat. No. CS-0447810
  • Molecule weight305.37
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(Tert-butoxycarbonyl)-4-phenylpiperidine-4-carboxylic acid|CS-0447810

Structure of 167262-68-2

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General Information

  • CAS No. 167262-68-2
  • Cat. No. CS-0447810
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₃NO₄
  • Molecular Weight 305.37
  • Synonym(s) N-BOC-4-PHENYL-4-piperidinecarboxylic acid
  • SMILES CC(C)(C)OC(=O)N1CCC(CC1)(C2=CC=CC=C2)C(=O)O

Description

1-(Tert-butoxycarbonyl)-4-phenylpiperidine-4-carboxylic acid features a sterically hindered tert-butyl ester group that confers enhanced stability and ease of handling. The pendant phenyl ring imparts rigidity and electron-rich character, while the carboxylic acid moiety enables direct conjugation or derivatization in synthetic sequences. This scaffold serves as a key building block for bioactive molecule development.

Synthesis

  • Route1

    References

    • Hoemann, Michael Z. Patent: US2002/177607 A1, 2002 ; US 20020177607 A1
  • Route2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      53484-76-7
    • ~%
    • In-stock
      1-(Tert-butoxycarbonyl)-4-phenylpiperidine-4-carboxylic acid|CS-0447810
      167262-68-2

    References

    • US5635510 A1, ; US 5635510 A
  • Route3
    • null|null
      158144-80-0
    • ~95%
    • In-stock
      1-(Tert-butoxycarbonyl)-4-phenylpiperidine-4-carboxylic acid|CS-0447810
      167262-68-2

    References

    • Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.84
  • LogP   3.0399
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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