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CS-W001157 4
Total: USD 88.00

N-Methyl-3-nitroaniline

  • CAS No. 619-26-1

  • Cat. No. CS-0011705
  • Purity≥98%
  • MDL No.MFCD00963641

*For research and further manufacturing use only, not for direct human use.

N-Methyl-3-nitroaniline|CS-0011705

Structure of 619-26-1

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General Information

  • CAS No. 619-26-1
  • Cat. No. CS-0011705
  • Purity ≥98%
  • MDL No. MFCD00963641
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₂
  • Molecular Weight 152.15
  • Synonym(s) None
  • SMILES CNC1=CC=CC([N+]([O-])=O)=C1

Description

N-Methyl-3-nitroaniline features a para-nitro group and a methylated aniline moiety, delivering enhanced electron-withdrawing character and improved solubility in organic solvents. This combination enables straightforward incorporation into synthetic routes requiring polar yet stable intermediates, particularly in the development of dyes, pharmaceuticals, and advanced materials.

Application

N-Methyl-3-nitroaniline serves as a versatile intermediate in synthetic organic chemistry, enabling efficient access to substituted anilines and heterocyclic scaffolds. Its nitro group facilitates reduction to amino derivatives under standard conditions, while the N-methyl functionality enhances solubility and modulates reactivity. The compound exhibits bench stability and compatibility with common functional groups, making it well-suited for multi-step synthesis and process development workflows.

Synthesis

  • Route1
    • null|null
      99-09-2
    • null|null
      74-88-4
    • ~96%
    • In-stock
      N-Methyl-3-nitroaniline|CS-0011705
      619-26-1

    References

    • Nagashima; Akamatsu; Kawaminami; Kawazoe; Ogami; Matsumoto; Okada; Suzuki; Tsukamoto Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 11 p. 1420 - 1432
  • Route2
    • null|null
      585-79-5
    • null|null
      74-89-5
    • ~94%
    • In-stock
      N-Methyl-3-nitroaniline|CS-0011705
      619-26-1

    References

    • Jiao, Jiao; Zhang, Xi-Ru; Chang, Ning-Hui; Wang, Jie; Wei, Jun-Fa; Shi, Xian-Ying; Chen, Zhan-Guo Journal of Organic Chemistry, 2011 , vol. 76, # 4 p. 1180 - 1183
  • Route3
    • N-(3-Nitrophenyl)-2,2,2-trifluoroacetamide|CS-0213497
      25080-83-5
    • null|null
      77-78-1
    • ~73%
    • In-stock
      N-Methyl-3-nitroaniline|CS-0011705
      619-26-1

    References

    • Brown, Samuel A.; Rizzo, Carmelo J. Synthetic Communications, 1996 , vol. 26, # 21 p. 4065 - 4080

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.17
  • LogP   1.6365
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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