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CS-W001157 4
Total: USD 88.00

tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate

  • CAS No. 167081-41-6

  • Cat. No. CS-W006787
  • Purity≥95%
  • MDL No.MFCD13659430
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate|CS-W006787

Structure of 167081-41-6

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Description

tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate features a hydroxyl-functionalized cyclobutyl scaffold that enables selective derivatization in synthetic workflows. The tert-butyl carbamate group provides robust protection for amine intermediates, offering stability under standard conditions while allowing straightforward deprotection when required. This compound serves as a key building block in the synthesis of bioactive cyclic amines and functionalized heterocycles.

Application

tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate serves as a stable, bench-friendly building block for cyclobutane-containing scaffolds. The protected amine enables sequential functionalization of the cyclobutyl ring, while the hydroxyl group offers direct access to derivatization via esterification or ether formation. Its compatibility with standard deprotection protocols and tolerance to diverse reaction conditions facilitates integration into complex molecule synthesis, including medicinal chemistry campaigns requiring rigid cyclic frameworks.

General Information

  • CAS No. 167081-41-6
  • Cat. No. CS-W006787
  • Purity ≥95%
  • MDL No. MFCD13659430
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₃
  • Molecular Weight 201.26
  • Synonym(s) Carbamic acid, N-[(3-hydroxycyclobutyl)methyl]-, 1,1-dimethylethyl ester
  • SMILES O=C(NCC1CC(C1)O)OC(C)(C)C

Computational Chemistry Data

  • TPSA   58.56
  • LogP   1.282
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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