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CS-W001157 4
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tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate

  • CAS No. 167081-41-6

  • Cat. No. CS-W006787
  • Molecule weight201.26
  • Purity≥95%
  • MDL No.MFCD13659430

*For research and further manufacturing use only, not for direct human use.

tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate|CS-W006787

Structure of 167081-41-6

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General Information

  • CAS No. 167081-41-6
  • Cat. No. CS-W006787
  • Purity ≥95%
  • MDL No. MFCD13659430
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₉NO₃
  • Molecular Weight 201.26
  • Synonym(s) Carbamic acid, N-[(3-hydroxycyclobutyl)methyl]-, 1,1-dimethylethyl ester
  • SMILES O=C(NCC1CC(C1)O)OC(C)(C)C

Description

tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate features a hydroxyl-functionalized cyclobutyl scaffold that enables selective derivatization in synthetic workflows. The tert-butyl carbamate group provides robust protection for amine intermediates, offering stability under standard conditions while allowing straightforward deprotection when required. This compound serves as a key building block in the synthesis of bioactive cyclic amines and functionalized heterocycles.

Application

tert-Butyl ((3-hydroxycyclobutyl)methyl)carbamate serves as a stable, bench-friendly building block for cyclobutane-containing scaffolds. The protected amine enables sequential functionalization of the cyclobutyl ring, while the hydroxyl group offers direct access to derivatization via esterification or ether formation. Its compatibility with standard deprotection protocols and tolerance to diverse reaction conditions facilitates integration into complex molecule synthesis, including medicinal chemistry campaigns requiring rigid cyclic frameworks.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   1.282
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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