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Total: USD 88.00

(1R,2S)-2-Fluorocyclopropane-1-carboxylic acid

  • CAS No. 167073-08-7

  • Cat. No. CS-0053630
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(1R,2S)-2-Fluorocyclopropane-1-carboxylic acid|CS-0053630

Structure of 167073-08-7

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General Information

  • CAS No. 167073-08-7
  • Cat. No. CS-0053630
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅FO₂
  • Molecular Weight 104.08
  • Synonym(s) Sitafloxacin Impurity 26
  • SMILES OC(=O)[C@H]1C[C@@H]1F

Description

This fluorinated cyclopropane carboxylic acid features a strained three-membered ring with a stereo-defined fluorine substituent, delivering enhanced metabolic stability and conformational rigidity. The (1R,2S) configuration enables precise spatial orientation in bioactive molecules, making it valuable for medicinal chemistry applications requiring defined geometry.

Application

(1R,2S)-2-Fluorocyclopropane-1-carboxylic acid serves as a conformationally constrained building block in medicinal chemistry, enabling the study of stereocontrolled bioactive molecule synthesis. Its fluorinated cyclopropane core imparts metabolic stability and modulates electronic properties, while the carboxylic acid functionality facilitates direct derivatization via amide formation, esterification, or coupling reactions. Bench-stable and readily purified by recrystallization, it functions reliably in standard peptide coupling and heterocycle construction workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅲ
Hazard Statements : H228
Precautionary Statements : P210-P240-P241-P280-P370+P378

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   0.429
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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