(1R)-2,2-Difluorocyclopropane-1-carboxylic acid

Name: (1R)-2,2-Difluorocyclopropane-1-carboxylic acid
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CAS No. 1631747-25-5
Cat. No. CS-0053638
Purity≥97%
MDL No.MFCD30719344

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(1R)-2,2-Difluorocyclopropane-1-carboxylic acid|CS-0053638

Structure of 1631747-25-5

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General Information

CAS No. 1631747-25-5
Cat. No. CS-0053638
Purity ≥97%
MDL No. MFCD30719344
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₄F₂O₂
Molecular Weight 122.07
Synonym(s) (1R)‐2,2‐difluorocyclopropane‐1‐carboxylic acid
SMILES OC(=O)[C@H]1CC1(F)F

Description

This chiral cyclopropane carboxylic acid features a rigid, strained ring system with two fluorine atoms at the geminal 2-position, conferring enhanced metabolic stability and distinct electronic properties. The (1R) stereochemistry enables selective incorporation into bioactive molecules, particularly in medicinal chemistry applications where conformational restraint and lipophilicity are critical.

Application

(1R)-2,2-Difluorocyclopropane-1-carboxylic acid serves as a conformationally constrained building block for medicinal chemistry campaigns, enabling the exploration of stereochemically defined bioactive scaffolds. Its rigid cyclopropane core imparts metabolic stability and enhances target binding affinity in peptidomimetic and CNS-targeted compound development. The difluoro substitution pattern modulates electronic properties and lipophilicity, while the carboxylic acid group facilitates direct derivatization or salt formation. Bench-stable and compatible with standard coupling protocols, it functions effectively in solid-phase synthesis and fragment-based drug discovery workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 37.3
LogP 0.7262
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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(1R)-2,2-Difluorocyclopropane-1-carboxylic acid

CAS No. 1631747-25-5

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