(1R,2R)-2-Fluorocyclopropanecarboxylicacid

Name: (1R,2R)-2-Fluorocyclopropanecarboxylicacid
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CAS No. 127199-13-7
Cat. No. CS-W020398
Purity≥97%
MDL No.MFCD19238080

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FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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(1R,2R)-2-Fluorocyclopropanecarboxylicacid|CS-W020398

Structure of 127199-13-7

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General Information

CAS No. 127199-13-7
Cat. No. CS-W020398
Purity ≥97%
MDL No. MFCD19238080
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₅FO₂
Molecular Weight 104.08
Synonym(s) Cyclopropanecarboxylic acid, 2-fluoro-, (1R-cis)-
SMILES O=C(O)[C@@H]1[C@@H](C1)F

Description

(1R,2R)-2-Fluorocyclopropanecarboxylic acid features a rigid, strained cyclopropane ring with stereocontrolled fluorine substitution, delivering enhanced metabolic stability and conformational constraint. This configuration enables precise incorporation into bioactive molecules where steric and electronic effects are critical.

Application

(1R,2R)-2-Fluorocyclopropanecarboxylic acid serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of fluorinated cyclopropyl-containing scaffolds. Its rigid cyclopropane ring imparts conformational constraint, while the carboxylic acid functionality facilitates direct derivatization into amides, esters, or acyl chlorides. The stereochemistry is stable under standard reaction conditions and supports orthogonal functional group transformations. This compound exhibits bench stability and ease of purification, making it well-suited for iterative synthetic campaigns in API development.

Safety Information

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GHS Pictogram :	GHS No : GHS05,GHS07
Signal Word : Danger	UN#: 3261
Class : 8	Packing Group : Ⅱ
Hazard Statements : H302-H314-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

TPSA 37.3
LogP 0.429
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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(1R,2R)-2-Fluorocyclopropanecarboxylicacid

CAS No. 127199-13-7

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