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Structure of 16633-50-4
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4-Fluoro-2,6-dimethyl benzoic acid features a fluorine atom at the para position relative to the carboxylic acid, paired with methyl groups at the ortho positions. This substitution pattern imparts enhanced lipophilicity and metabolic stability, making the compound valuable for medicinal chemistry applications where improved membrane permeability and resistance to oxidative degradation are required.
4-Fluoro-2,6-dimethyl benzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-withdrawing fluorine substituent enhances metabolic stability, while the ortho-methyl groups provide steric protection and influence regioselectivity in downstream transformations. The carboxylic acid functionality facilitates direct coupling reactions, amidation, and esterification under standard conditions, offering reliable access to diverse analogs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: