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CS-W001157 4
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6-Chloro-3-quinolinecarboxylic acid

  • CAS No. 118791-14-3

  • Cat. No. CS-W008667
  • Purity≥95%
  • MDL No.MFCD09787826
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

6-Chloro-3-quinolinecarboxylic acid|CS-W008667

Structure of 118791-14-3

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Description

6-Chloro-3-quinolinecarboxylic acid features a chlorinated quinoline core with a carboxylic acid group at the 3-position, enabling direct conjugation or derivatization. This electron-deficient scaffold integrates readily into synthetic routes for pharmaceutical intermediates, offering enhanced reactivity and metabolic stability in bioactive molecule design.

Application

6-Chloro-3-quinolinecarboxylic acid serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling direct functionalization at the C-3 position via coupling reactions. Its chloro substituent facilitates nucleophilic aromatic substitution, while the carboxylic acid group supports amide formation, esterification, or metal complexation. The molecule exhibits good bench stability and compatibility with standard purification techniques, making it well-suited for iterative synthesis of quinoline-based pharmaceuticals and agrochemical scaffolds.

General Information

  • CAS No. 118791-14-3
  • Cat. No. CS-W008667
  • Purity ≥95%
  • MDL No. MFCD09787826
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆ClNO₂
  • Molecular Weight 207.61
  • Synonym(s) 6-Chloroquinoline-3-carboxylic acid
  • SMILES O=C(C1=CC2=CC(Cl)=CC=C2N=C1)O

Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.5864
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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