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CS-W001157 4
Total: USD 88.00

7-Chloro-3-quinolinecarboxylic acid

  • CAS No. 892874-49-6

  • Cat. No. CS-0021508
  • Purity≥95%
  • MDL No.MFCD08437567

*For research and further manufacturing use only, not for direct human use.

7-Chloro-3-quinolinecarboxylic acid|CS-0021508

Structure of 892874-49-6

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General Information

  • CAS No. 892874-49-6
  • Cat. No. CS-0021508
  • Purity ≥95%
  • MDL No. MFCD08437567
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆ClNO₂
  • Molecular Weight 207.61
  • Synonym(s) 7-Chloroquinoline-3-carboxylic acid
  • SMILES O=C(C1=CC2=CC=C(Cl)C=C2N=C1)O

Description

7-Chloro-3-quinolinecarboxylic acid features a chlorinated quinoline core with a carboxylic acid group at the 3-position, enabling direct conjugation in synthetic transformations. This electron-deficient scaffold integrates readily into bioactive molecule frameworks, offering enhanced metabolic stability and targeted binding affinity in medicinal chemistry applications.

Application

7-Chloro-3-quinolinecarboxylic acid serves as a versatile building block for the synthesis of quinoline-based pharmaceuticals and agrochemicals. Its carboxylic acid functionality enables direct coupling reactions, while the chloro substituent at the 7-position provides a handle for palladium-catalyzed cross-coupling transformations. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative medicinal chemistry campaigns and scale-up processes.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.5864
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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