Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Fluoro-2,6-dimethyl benzoic acid

  • CAS No. 16633-50-4

  • Cat. No. CS-0110464
  • Purity≥98%
  • MDL No.MFCD06208279

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-2,6-dimethyl benzoic acid|CS-0110464

Structure of 16633-50-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 16633-50-4
  • Cat. No. CS-0110464
  • Purity ≥98%
  • MDL No. MFCD06208279
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉FO₂
  • Molecular Weight 168.16
  • Synonym(s) Benzoic acid, 4-fluoro-2,6-dimethyl-
  • SMILES O=C(O)C1=C(C)C=C(F)C=C1C

Description

4-Fluoro-2,6-dimethyl benzoic acid features a fluorine atom at the para position relative to the carboxylic acid, paired with methyl groups at the ortho positions. This substitution pattern imparts enhanced lipophilicity and metabolic stability, making the compound valuable for medicinal chemistry applications where improved membrane permeability and resistance to oxidative degradation are required.

Application

4-Fluoro-2,6-dimethyl benzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its electron-withdrawing fluorine substituent enhances metabolic stability, while the ortho-methyl groups provide steric protection and influence regioselectivity in downstream transformations. The carboxylic acid functionality facilitates direct coupling reactions, amidation, and esterification under standard conditions, offering reliable access to diverse analogs.

Synthesis

  • Route1

    References

    • SCHERING CORPORATION Patent: EP1175401 B1, 2005 ; Location in patent: Page/Page column 30 ;
  • Route2
    • 4-Fluoro-2,6-dimethylbenzamide|CS-1187431
      16643-19-9
    • ~%
    • In-stock
      4-Fluoro-2,6-dimethyl benzoic acid|CS-0110464
      16633-50-4

    References

    • Journal of the American Chemical Society, , vol. 89, # 2 p. 390 - 394
  • Route3
    • 3,5-Dimethyl-4-nitrobenzoic acid|CS-0206008
      3095-38-3
    • ~%
    • In-stock
      4-Fluoro-2,6-dimethyl benzoic acid|CS-0110464
      16633-50-4

    References

    • Journal of the American Chemical Society, , vol. 89, # 2 p. 390 - 394

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.14074
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Fluoro-2,6-dimethyl benzoic acid sigma4-Fluoro-2,6-dimethyl benzoic acid manufacturer4-Fluoro-2,6-dimethyl benzoic acid price4-Fluoro-2,6-dimethyl benzoic acid structure4-Fluoro-2,6-dimethyl benzoic acid SDSbuy 4-Fluoro-2,6-dimethyl benzoic acid4-Fluoro-2,6-dimethyl benzoic acid supplier4-Fluoro-2,6-dimethyl benzoic acid uses4-Fluoro-2,6-dimethyl benzoic acid molecular weightprice of 4-Fluoro-2,6-dimethyl benzoic acid4-Fluoro-2,6-dimethyl benzoic acid chemical name formula of 4-Fluoro-2,6-dimethyl benzoic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label