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CS-W001157 4
Total: USD 88.00

5-Fluoro-4-iodopyridin-2-amine

  • CAS No. 1649470-53-0

  • Cat. No. CS-0050477
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-4-iodopyridin-2-amine|CS-0050477

Structure of 1649470-53-0

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General Information

  • CAS No. 1649470-53-0
  • Cat. No. CS-0050477
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄FIN₂
  • Molecular Weight 238.00
  • Synonym(s) 5-Fluoro-4-iodo-2-pyridinamine
  • SMILES NC1=CC(I)=C(F)C=N1

Description

5-Fluoro-4-iodopyridin-2-amine features a strategically positioned fluorine and iodine substituent on the pyridine ring, enabling facile cross-coupling reactions. The electron-deficient aromatic core pairs with the nucleophilic amine group to deliver high reactivity in palladium-catalyzed transformations. This compound serves as a key building block for bioactive heterocycles and pharmaceutical intermediates under standard coupling conditions.

Application

5-Fluoro-4-iodopyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its iodine functionality. The fluorinated pyridine scaffold provides enhanced metabolic stability and modulates electronic properties, while the amine group facilitates further derivatization. This compound exhibits good bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.4075
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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