(1S,2S)-2-Fluorocyclopropan-1-amine hydrochloride

Name: (1S,2S)-2-Fluorocyclopropan-1-amine hydrochloride
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CAS No. 1638744-20-3
Cat. No. CS-0143348
Purity≥97%
MDL No.MFCD28501448

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(1S,2S)-2-Fluorocyclopropan-1-amine hydrochloride|CS-0143348

Structure of 1638744-20-3

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General Information

CAS No. 1638744-20-3
Cat. No. CS-0143348
Purity ≥97%
MDL No. MFCD28501448
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₇ClFN
Molecular Weight 111.55
Synonym(s) (1S,2S)-2-fluorocyclopropan-1-aminehydrochloride
SMILES N[C@@H]1[C@@H](F)C1.[H]Cl

Description

This fluorinated cyclopropane derivative features a chiral amine core with enhanced metabolic stability. The fluorine atom at the 2-position imparts conformational rigidity and modulates electronic properties, enabling precise control in medicinal chemistry applications. Delivers a potent bioisostere for amino acid side chains.

Application

(1S,2S)-2-Fluorocyclopropan-1-amine hydrochloride serves as a conformationally constrained chiral building block for medicinal chemistry and catalytic synthesis. Its fluorinated cyclopropane core imparts metabolic stability and enhances binding affinity in bioactive molecules. The amine functionality enables straightforward derivatization via alkylation, acylation, or reductive amination, while the hydrochloride salt ensures excellent bench stability and ease of handling. This compound functions as a key scaffold in the synthesis of fluorinated analogs of biologically active compounds.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 26.02
LogP 0.4773
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(1S,2S)-2-Fluorocyclopropan-1-amine hydrochloride

CAS No. 1638744-20-3

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