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*For research and further manufacturing use only, not for direct human use.
Structure of 163759-49-7
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2'-O-MOE-5-Me-rU is a modified ribonucleoside featuring a 2'-O-methoxyethyl group and a methyl substituent at the 5-position of uracil. This combination enhances nuclease resistance and binding affinity while maintaining favorable pharmacokinetic properties. The moiety integrates seamlessly into oligonucleotide sequences for therapeutic applications.
2'-O-MOE-5-Me-rU serves as a robust nucleoside building block for antisense oligonucleotide synthesis, combining the enhanced nuclease resistance of 2'-O-methoxyethyl (MOE) modification with the stabilizing effect of 5-methylcytosine analogs. Its improved pharmacokinetic profile and compatibility with standard phosphoramidite chemistry facilitate efficient incorporation into therapeutic sequences, enabling prolonged target engagement in clinical applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H320-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: