Lot numbers can be found on the outside label of a product:
N-Acetylserine
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CAS No. 16354-58-8
- Cat. No. CS-0167102
- Purity≥97%
- MDL No.MFCD09952005
*For research and further manufacturing use only, not for direct human use.
Structure of 16354-58-8
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General Information
- CAS No. 16354-58-8
- Cat. No. CS-0167102
- Purity ≥97%
- MDL No. MFCD09952005
- Storage -20°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₉NO₄
- Molecular Weight 147.13
- Synonym(s) N-Acetyl-L-serine
- SMILES OC[C@@H](C(O)=O)NC(C)=O
Description
N-Acetylserine features a protected amino group paired with a reactive hydroxyl side chain, enabling direct incorporation into peptide sequences without side-chain modification. This stability under standard conditions simplifies handling in synthetic workflows and supports efficient conjugation chemistry for bioconjugate development.
Application
N-Acetylserine serves as a stable, bench-ready precursor for serine-derived motifs in peptide synthesis and medicinal chemistry. Its acetylated amine enhances solubility and reduces side reactions during coupling, while the hydroxyl group enables selective derivatization. Functions reliably in standard SPPS workflows and facilitates access to bioactive heterocycles and chiral building blocks.
Synthesis
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Route1
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In-stock
56-45-1 -
108-24-7 - ~83%
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In-stock
16354-58-8
References
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Zheng, Yan; Duanmu, Chuansong; Gao, Yong Organic Letters, 2006 , vol. 8, # 15 p. 3215 - 3217
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Route2
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In-stock
5680-80-8 -
64-19-7
- ~%
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In-stock
16354-58-8
References
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FUJISAWA PHARMACEUTICAL CO., LTD. Patent: WO2004/111041 A1, 2004 ; Location in patent: Page 49-50 ; WO 2004/111041 A1
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Route3
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2311-26-4
- ~%
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In-stock
16354-58-8
References
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CARLSON, Erin E.; TRADER, Darci Patent: US2014/107328 A1, 2014 ; Location in patent: Paragraph 0081-0082 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 86.63
- LogP -1.432
- H_Acceptors 3
- H_Donors 3
- Rotatable_Bonds 3
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