N-Acetyl-O-(1,1-dimethylethyl)-L-serine

Name: N-Acetyl-O-(1,1-dimethylethyl)-L-serine
Brand: ChemScene
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CAS No. 77285-09-7
Cat. No. CS-0208963
Purity≥98%
MDL No.MFCD00236770

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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N-Acetyl-O-(1,1-dimethylethyl)-L-serine|CS-0208963

Structure of 77285-09-7

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General Information

CAS No. 77285-09-7
Cat. No. CS-0208963
Purity ≥98%
MDL No. MFCD00236770
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₇NO₄
Molecular Weight 203.24
Synonym(s) AC-Ser(tbu)-OH
SMILES CC(N[C@H](C(O)=O)COC(C)(C)C)=O

Description

N-Acetyl-O-(1,1-dimethylethyl)-L-serine features a protected hydroxyl group and acetylated amine, enabling stable incorporation into peptide synthesis. The tert-butyl ether moiety provides robust protection against side reactions, while the acetyl group enhances solubility and compatibility with standard coupling protocols. This derivative simplifies the introduction of serine residues in complex sequences under mild conditions.

Application

N-Acetyl-O-(1,1-dimethylethyl)-L-serine serves as a stable, bench-ready serine surrogate enabling efficient access to peptide backbones and chiral building blocks. Its tert-butyl ether protection ensures high functional group tolerance and compatibility with standard coupling protocols, while the acetyl group facilitates controlled deprotection under mild conditions. Ideal for fragment-based synthesis and heterocycle construction, it streamlines the preparation of complex scaffolds in medicinal chemistry workflows.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 0.3908
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 4

Other Classifications

Life Science Amino Acids and their Derivatives Serine and derivatives

Building Blocks Functional Group Ether

Building Blocks Functional Group Amide

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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N-Acetyl-O-(1,1-dimethylethyl)-L-serine

CAS No. 77285-09-7

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