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CS-W001157 4
Total: USD 88.00

(2,5-Dimethylthiophen-3-yl)boronic acid

  • CAS No. 162607-23-0

  • Cat. No. CS-0038853
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(2,5-Dimethylthiophen-3-yl)boronic acid|CS-0038853

Structure of 162607-23-0

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General Information

  • CAS No. 162607-23-0
  • Cat. No. CS-0038853
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉BO₂S
  • Molecular Weight 156.01
  • Synonym(s) 2,5-Dimethylthiophene-3-boronic acid
  • SMILES CC1=CC(=C(C)S1)B(O)O

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering functionalized heteroaryl products with high efficiency. The dimethylthiophene scaffold imparts enhanced stability and solubility, enabling reliable performance in complex synthetic sequences.

Application

(2,5-Dimethylthiophen-3-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its thiophene core offers enhanced stability and favorable solubility, while the boronic acid group facilitates reliable coupling under mild conditions. The 2,5-dimethyl substitution pattern provides steric and electronic modulation, improving functional group tolerance and simplifying purification. This reagent is well-suited for medicinal chemistry campaigns requiring access to substituted thiophene derivatives.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.04474
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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