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CS-W001157 4
Total: USD 88.00

1-Cyclopropyl-1H-pyrazole-4-carboxylic acid

  • CAS No. 1622883-44-6

  • Cat. No. CS-0052578
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropyl-1H-pyrazole-4-carboxylic acid|CS-0052578

Structure of 1622883-44-6

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General Information

  • CAS No. 1622883-44-6
  • Cat. No. CS-0052578
  • Purity ≥98%
  • MDL No. None
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O₂
  • Molecular Weight 152.15
  • Synonym(s) None
  • SMILES OC(=O)C1=CN(N=C1)C1CC1

Description

1-Cyclopropyl-1H-pyrazole-4-carboxylic acid features a rigid pyrazole core with a cyclopropyl substituent at the 1-position and a carboxylic acid group at the 4-position. This combination delivers enhanced metabolic stability and favorable physicochemical properties, making it a valuable scaffold in medicinal chemistry for targeted drug discovery programs.

Application

1-Cyclopropyl-1H-pyrazole-4-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its pyrazole core provides robust stability and favorable pharmacokinetic properties, while the carboxylic acid functionality enables direct coupling reactions or derivatization. The cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, offering a valuable scaffold for optimizing target affinity in bioactive molecule design.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.9162
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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