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CS-W001157 4
Total: USD 88.00

1-Cyclopropyl-1H-pyrazole-4-carbaldehyde

  • CAS No. 1082066-00-9

  • Cat. No. CS-0161804
  • Molecule weight136.15
  • Purity≥97%
  • MDL No.MFCD19687735

*For research and further manufacturing use only, not for direct human use.

1-Cyclopropyl-1H-pyrazole-4-carbaldehyde|CS-0161804

Structure of 1082066-00-9

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General Information

  • CAS No. 1082066-00-9
  • Cat. No. CS-0161804
  • Purity ≥97%
  • MDL No. MFCD19687735
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈N₂O
  • Molecular Weight 136.15
  • Synonym(s) None
  • SMILES O=CC1=CN(C2CC2)N=C1

Description

1-Cyclopropyl-1H-pyrazole-4-carbaldehyde features a cyclopropyl group attached to a pyrazole scaffold, delivering enhanced lipophilicity and metabolic stability. The aldehyde functionality enables direct coupling in Ugi-type reactions or reductive amination workflows. This compound serves as a key building block for bioactive heterocycles and pharmaceutical intermediates.

Application

1-Cyclopropyl-1H-pyrazole-4-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazole-based heterocycles. Its aldehyde functionality facilitates nucleophilic additions, reductive aminations, and condensation reactions under mild conditions. The cyclopropyl substituent enhances metabolic stability and modulates lipophilicity, offering favorable physicochemical properties for drug discovery applications. Bench-stable and compatible with standard purification methods, it functions reliably in multistep syntheses.

Synthesis

  • Route1
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      4333-56-6
    • In-stock
      1H-Pyrazole-4-carbaldehyde|CS-W019597
      35344-95-7
    • ~%
    • In-stock
      1-Cyclopropyl-1H-pyrazole-4-carbaldehyde|CS-0161804
      1082066-00-9

    References

    • ELI LILLY AND COMPANY Patent: WO2008/141020 A1, 2008 ; Location in patent: Page/Page column 61 ; WO 2008/141020 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.89
  • LogP   1.0305
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

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