Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

Name: Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH
Brand: ChemScene
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CAS No. 1599440-20-6
Cat. No. CS-0168722
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH|CS-0168722

Structure of 1599440-20-6

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General Information

CAS No. 1599440-20-6
Cat. No. CS-0168722
Purity ≥98%
MDL No. None
Storage 4°C, stored under nitrogen, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₈H₂₅N₅O₇
Molecular Weight 423.42
Synonym(s) None
SMILES OC(COCNC(CNC([C@@H](NC(CNC(CN)=O)=O)CC1=CC=CC=C1)=O)=O)=O

Description

This tetrapeptide derivative features a C-terminal ester-linked carboxylic acid, combining peptide backbone stability with enhanced solubility. The Gly-Gly-Phe-Gly sequence provides a rigid, hydrophobic core, while the N-terminal amidation and O-alkylated side chain enable controlled reactivity in bioconjugation workflows.

Application

Gly-Gly-Phe-Gly-NH-CH₂-O-CH₂COOH serves as a stable, readily accessible peptide-based building block for the synthesis of bioactive oligopeptide scaffolds. Its N-terminal hydroxymethyl carbamate functionality enables selective derivatization and conjugation in solid-phase and solution-phase peptide coupling protocols. The sequence exhibits good bench stability and facilitates orthogonal functional group manipulation, supporting efficient access to cyclic analogs and peptidomimetic architectures in medicinal chemistry campaigns.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 188.95
LogP -2.9201
H_Acceptors 7
H_Donors 6
Rotatable_Bonds 13

Other Classifications

Life Science Linker Peptide Linkers

Life Science ADC Related Compound ADC Linker

Chemical Biology PEGylation PEG Oligomers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

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Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

CAS No. 1599440-20-6

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